ABSTRACT. Heidmann M.J., Fischer V.L., Manhezzo T.G., Santos J.D., Castro B.G. [Retrospective Study of Equine Infectious Anemia in Central-Southern of the State of Pará, Brasil, 2007-2010]. Estudo Retrospectivo da Anemia Infecciosa Equina na Região Centro-Sul do Pará, Brasil, 2007-2010. Revista Brasileira de Medicina Veterinária, 34(3):192-197, 2012. Instituto de Ciências da Saúde, Campus Universitário de Sinop, Universidade Federal de Mato Grosso, Avenida Alexandre Ferronato, 1200, Setor Industrial, Sinop 78557-267, MT, Brasil. E-mail: firstname.lastname@example.org The Equine Infectious Anemia (EIA) is an important disease in Equine Sanity by the economic losses and progressive debility of the animals or, mainly, by the obligatory sacrifice in several States in Brazil. Thus, this study aimed to detect the prevalence of EIA in equids in the Central-Southern Region of the State of Pará, Brazil during the moths of January, 2007 to December, 2010. It was evaluated 1,626 EIA tests of two official laboratories from Sinop and Colíder, both in the State of MatoGrosso. According to the results, from de total of examined animals, eight were asinine, 991equines and 627 mules. The annual prevalence of EIA in the refereed region during the years from 2007 to 2010 was 36.36; 13.33; 9.70 and7.06%, respectively. The obtained result showed higherprevalence when compared to others Regions in Brazil, demonstrating the necessity to maintaining public policy of Animal Sanity to keep the prevalence in acceptable levels.