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ABSTRACT. Ferrer M.T., de Melo S.R., Pimentel J. de L., Pinheiro Junior J.W. & Brandespim D.F. [Analysis of occupational risk and antirrabies prophylactic treatment in health and endemic agents.] Análise do risco ocupacional e do tratamento profilático antirrábico em agentes de endemia e de saúde. Revista Brasileira de Medicina Veterinária, 36(3):307-311, 2014. Curso de Medicina Veterinária, Unidade Acadêmica de Garanhuns, Universidade Federal Rural de Pernambuco, Av. Bom Pastor, s/n°, Boa Vista, Garanhuns, PE 55292-270, Brasil. E-mail: firstname.lastname@example.org This paper aimed to assess the risk of exposure and conduct of prophylactic antirrabies treatment established by health care providers and the endemics Municipality of Garanhuns, PE during their professional activities. We conducted a descriptive epidemiological study of retrospective type, from data collection through the application of a semi-structured questionnaire containing open and closed questions, to 192 professionals, 168 health agents and 24 agents of the municipality of endemics Garanhuns -PE. Of the 192 interviewed agents, 14.1% (27/165) had been attacked by animals during their occupation activities. On the post-exposure prophylactic treatment, it was found that 44.5% (12/27) received-vaccination serum, 37% (10/27) did not undergo any treatment, while only 18.5% (5/27) had the wound washed with soap and water. Was concluded that there is a lack of basic information regarding both the pre-exposure or post-exposure prophylaxis of rabies in professionals like agents that act with both health and / or endemic diseases and it is suggested both the improvement of their professional skills as the preexposure immunization as prophylactic measure to minimize the occupational risk in function of their field activities.