Retrospective study of retroviruses by immunoenzymatic test on cats in Grande Vitória (ES, Brazil) and associated neoplasms
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Keywords

Epidemiologia, retrovírus felinos, câncer, ELISA. Epidemiology, feline retrovirus, Cancer, ELISA.

How to Cite

Oliveira Almeida, I. ., Arnoni Alves da Silva, M. ., Voltolin de Sena, B. ., Saraiva da Paz, J. ., de Almeida Jaretta, T. ., Camargo Granadeiro Faria, P., & dos Santos Horta, R. . (2021). Retrospective study of retroviruses by immunoenzymatic test on cats in Grande Vitória (ES, Brazil) and associated neoplasms. Brazilian Journal of Veterinary Medicine, 43(1), e114220. https://doi.org/10.29374/2527-2179.bjvm114220

Abstract

Retroviruses are among the leading causes of death in domestic cats. Retroviruses associate with the host cell in a persistent and permanent way, leading to diverse clinical conditions. The feline leukemia virus (FeLV) is the most pathogenic retrovirus with the potential to cause both degenerative diseases and immunosuppression, as well as proliferative diseases, as its association with the cell may lead to a direct oncogenic effect. The feline immunodeficiency virus (FIV), in turn, can lead to the classic immunodeficiency syndrome, usually has a chronic, less aggressive course and has no direct oncogenic effect. The use of vaccines and control measures has resulted in a decrease in the prevalence of FeLV in the United States of America (USA) and Europe, however, in Brazil, statistics show prevalence rates above 50%. This study aimed to assess the prevalence of feline retroviruses, by immunoenzymatic assay testing, in the region of Grande Vitória, in Espírito Santo and also point out the frequency of neoplasms in these cats. A total of 388 cats were retrospectively evaluated (2014-2016). The prevalence of FIV was 2.3% and FeLV was 33.7%. Neoplasms were identified in the three cats seropositive for FIV and FeLV and in three cats infected only with FIV. Neoplasms were also found in 26.6% of cats that were seropositive only for FeLV, especially mediastinal lymphoma. The high prevalence of FeLV demonstrated in this study highlights the need for establishing effective control measures, with emphasis on vaccination.

https://doi.org/10.29374/2527-2179.bjvm114220
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References

Almeida, N. R., Danelli, M. G. M., Silva, L. H. P., Hagiwara, M. K., & Mazur, C. (2012). Prevalence of feline leukemia virus infection in domestic cats in Rio de Janeiro. Journal of Feline Medicine and Surgery, 14(8), 583-586. http://dx.doi.org/10.1177/1098612X12444693. PMid:22492347.

Bandecchi, P., Dell’omodarme, M., Magi, M., Palamidessi, A., & Prati, M. C. (2006). Feline leukaemia virus (FeLV) and feline immunodeficiency virus infections in cats in the Pisa district of Tuscany, and attempts to control FeLV infection in a colony of domestic cats by vaccination. The Veterinary Record, 158(16), 555-557. http:// dx.doi.org/10.1136/vr.158.16.555. PMid:16632529.

Biezus, G., Machado, G., Ferian, P. E., da Costa, U. M., Pereira, L. H. H. D. S., Withoeft, J. A., Nunes, I. A. C., Muller, T. R., de Cristo, T. G., & Casagrande, R. A. (2019). Prevalence of and factors associated with feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) in cats of the state of Santa Catarina, Brazil. Comparative Immunology, Microbiology and Infectious Diseases, 63, 17-21. http://dx.doi.org/10.1016/j.cimid.2018.12.004. PMid:30961813.

Coelho, F. M., Maia, M. Q., Luppi, M. M., Costa, E. A., Luiz, A. P. M. F., Ribeiro, N. A., Bomfim, M. R. Q., Fonseca, F. G., & Resende, M. (2011). Ocorrência do vírus da leucemia felina em Feliscattus em Belo Horizonte. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 63(3), 778-783. http://dx.doi.org/10.1590/S0102-09352011000300037.

Egenvall, A., Nødtvedt, A., Häggström, J., Ström Holst, B., Möller, L., & Bonnett, B. N. (2009). Mortality of Life- Insured Swedish cats during 1999-2006: Age, breed, sex, and diagnosis. Journal of Veterinary Internal Medicine, 23(6), 1175-1183. http://dx.doi.org/10.1111/j.1939-1676.2009.0396.x. PMid:19780926.

Hagiwara, M. K., Reche, A., & Lucas, S. R. R. (1997). Estudo clínico da infecção de felinos pelo vírus da leucemia felina em São Paulo. Revista Brasileira de Ciência Veterinária, 4(1), 35-38. http://dx.doi.org/10.4322/rbcv.2015.065.

Hartmann, K. (2012). Clinical aspects of feline retroviruses: a review. Viruses, 4(11), 2684-2710. http://dx.doi. org/10.3390/v4112684. PMid:23202500.

Herring, E. S., Troy, G. C., Toth, T. E., Forrester, S. D., Weigt, L. A., & Herring, I. P. (2001). Detection of feline leukaemia virus in blood and bone marrow of cats with varying suspicion of latent infection. Journal of Feline Medicine and Surgery, 3(3), 133-141. http://dx.doi.org/10.1053/jfms.2001.0132. PMid:11876630.

Hofmann-lehmann, R., Tandon, R., Boretti, F. S., Meli, M. L., Willi, B., Cattori, V., Gomes-Keller, M. A., Ossent, P., Golder, M. C., Flynn, J. N., & Lutz, H. (2006). Reassessment of feline leukaemia virus (FeLV) vaccines with novel sensitive molecular assays. Vaccine, 24(8), 1087-1094. http://dx.doi.org/10.1016/j.vaccine.2005.09.010. PMid:16198454.

Hosie, M. J., Robertson, C., & Jarrett, O. (1989). Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. The Veterinary Record, 125(11), 293-297. http://dx.doi. org/10.1136/vr.125.11.293. PMid:2554556.

Ito, J., Watanabe, S., Hiratsuka, T., Kuse, K., Odahara, Y., Ochi, H., Kawamura, M., & Nishigaki, K. (2013). Refrex-1, a soluble restriction factor against feline endogenous and exogenous retroviruses. Journal of Virology, 87(22), 12029-12040. http://dx.doi.org/10.1128/JVI.01267-13. PMid:23966402.

Jarrett, W. F., Crawford, E. M., Martin, W. B., & Davie, F. (1964). A virus-like particle associated with leukaemia (lymphosarcoma). Nature, 202(4932), 567-569. http://dx.doi.org/10.1038/202567a0. PMid:14195054.

Levy, J. K., Crawford, P. C., Kusuhara, H., Motokawa, K., Gemma, T., Watanabe, R., Arai, S., Bienzle, D., & Hohdatsu, T. (2008). Differentiation of feline immunodeficiency virus vaccination, infection, or vaccination and infection in cats. Journal of Veterinary Internal Medicine, 22(2), 330-334. http://dx.doi.org/10.1111/j.1939-1676.2008.0078.x. PMid:18371028.

Levy, J. K., Scott, H. M., Lachtara, J. L., & Crawford, P. C. (2006). Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in north america and risk factors for seropositivity. Journal of the American Veterinary Medical Association, 228(3), 371-376. http://dx.doi.org/10.2460/javma.228.3.371. PMid:16448357.

Little, S., Levy, J., Hartmann, K., Hofmann-Lehmann, R., Hosie, M., Olah, G., & Denis, K. S. (2020). AAFP feline retrovirus testing and management guidelines. Journal of Feline Medicine and Surgery, 22(1), 5-30. http:// dx.doi.org/10.1177/1098612X19895940. PMid:31916872.

Mendes-de-Almeida, F., Faria, M. C. F., Branco, A. S., Serrão, M. L., Souza, A. M., Almosny, N., Charme, M., & Labarthe, N. (2004). Sanitary Conditions of a colony of urban feral cats (Felis catus, Linnaeus, 1758) in a Zoological Garden in Rio de Janeiro, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, 46(5), 269-274. http:// dx.doi.org/10.1590/S0036-46652004000500007. PMid:15517031.

Miyake, A., Watanabe, S., Hiratsuka, T., Ito, J., Ngo, M. H., Makundi, I., Kawasaki, J., Endo, Y., Tsujimoto, H., & Nishigaki, K. (2016). Novel feline leukemia virus interference group based on the ENV gene. Journal of Virology, 90(9), 4832-4837. http://dx.doi.org/10.1128/JVI.03229-15. PMid:26889025.

Modiano, J. F., Henry, C. J., & Macy, D. W. (2013). The etiology of cancer. In S. J. Withrow, D. M. Vail & R. L. Page (Eds.), Withrow and MacEwan’s small animal clinical oncology (5th ed., pp. 1-29). USA: Elsevier Saunders.

Ogilvie, G. K., Tompkins, M. B., & Tompkins, W. A. (1988). Clinical and immunologic aspects of FeLV-induced immunosuppression. Veterinary Microbiology, 17(3), 287-296. http://dx.doi.org/10.1016/0378-1135(88)90070-3. PMid:2847393.

Pedersen, N. C., Ho, E. W., Brown, M. L., & Yamamoto, J. K. (1987). Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science, 235(4790), 790-793. http://dx.doi.org/10.1126/ science.3643650. PMid:3643650.

Poli, A., Abramo, F., Baldinotti, F., Pistello, M., Da Prato, L., & Bendinelli, M. (1994). Malignant lymphoma associated with experimentally induced feline immunodeficiency virus infection. Journal of Comparative Pathology, 110(4), 319-328. http://dx.doi.org/10.1016/S0021-9975(08)80309-X. PMid:7914523.

Quimby, J. M., Elston, T., Hawley, J., Brewer, M., Miller, A., & Lappin, M. R. (2008). Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. Journal of Feline Medicine and Surgery, 10(1), 66-72. http://dx.doi. org/10.1016/j.jfms.2007.05.007. PMid:17766156.

Ravazzolo, A. P. & Costa, U. (2007). Retroviroses. In Flores, E.F. (Ed.), Virologia Veterinária (pp. 811- 836). Santa Maria, Rio Grande do Sul: Editora da Universidade Federal de Santa Maria.

Rojko, J. L., & Hardy, W. D. (1994). Feline leukemia virus and other retroviruses. In R. G. Sherding, (Eds.), The cat diseases and clinical management (2nd ed., pp. 263-432). London: Churchill Livingstone.

Shelton, G. H., Grant, C. K., Cotter, S. M., Gardner, M. B., Hardy Junior, W. D., & DiGiacomo, R. F. (1990). Feline immunodeficiency virus and feline leukemia virus infection and their relationships to lymphoid malignancies in cats: a retrospective study (1968-1988). Journal of Acquired Immune Deficiency Syndromes, 3(6), 623-630. PMid:2159993.

Souza, H. J. M., Teixeira, C. H. R., & Graça, R. F. S. (2002). Estudo epidemiológico de infecções pelo vírus da leucemia e/ou imunodeficiência felina, em gatos domésticos do município do Rio de Janeiro. La Clinica Veterinaria, 36(36), 14-21.

Teixeira, B. M., Rajão, D. S., Haddad, J. P. A., Leite, R. C., & Reis, J. K. P. (2007). Ocorrência do vírus da imunodeficiência felina e do vírus da leucemia felina em gatos domésticos mantidos em abrigos no município de Belo Horizonte. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 59(4), 939-947. http://dx.doi.org/10.1590/ S0102-09352007000400019.

Westman, M. E., Malik, R., Hall, E., Sheehy, P. A., & Norris, J. M. (2015). Determining the feline immunodeficiency virus (FIV) status of FIV-vaccinated cats using point-of-care antibody kits. Comparative Immunology, Microbiology and Infectious Diseases, 42, 43-52. http://dx.doi.org/10.1016/j.cimid.2015.07.004. PMid:26459979.

Yilmaz, H., Ilgaz, A., & Harbour, D. (2000). A prevalence of FIV and FeLV infections in cats in Istanbul. Journal of Feline Medicine and Surgery, 2(1), 69-70. http://dx.doi.org/10.1053/jfms.2000.0066. PMid:11716594.

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Copyright (c) 2021 Isabella Oliveira Almeida, Mariana Arnoni Alves da Silva, Bruna Voltolin de Sena, Jeanne Saraiva da Paz, Tamara de Almeida Jaretta, Priscila Camargo Granadeiro Faria, Rodrigo dos Santos Horta