Detomidine and xylazine, at different doses, in donkeys (Equus asinus)
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Keywords

alpha-2 adrenergic agonist
analgesia
equine
sedation

How to Cite

Parentoni, R. N., Henrique, F. V., Brasil, A. W. de L., Dias, R. A., Araújo, A. L. de A., Mendes, R. de S., Martins Filho, E. F., Costa Neto, J. M. da, de Souza, A. P., & da Nóbrega Neto, P. I. (2021). Detomidine and xylazine, at different doses, in donkeys (Equus asinus). Brazilian Journal of Veterinary Medicine, 42(1), e100820. https://doi.org/10.29374/2527-2179.bjvm100820

Abstract

The effects of detomidine and xylazine in northeasters donkeys were compared. Six animals participated, randomly, of all experimental groups: xylazine 10%, 0.8 mg/kg (xylazine group 0.8 - GX0.8), 1.0 mg/kg (GX1.0) and 1, 2 mg/kg (GX1.2); and detomidine 1%, 0.02 mg/kg (Detomidine group 0.02 - GD0.02), 0.04 mg/kg (GD0.04) and 0.06 mg/kg (GD0.06) intravenous. Heart rate (HR) and respiratory rate (RR), rectal temperature (RT), mean arterial pressure (MAP), blood glucose, sedation, analgesia, ataxia, arrhythmias and urination were monitored. Duration of sedation was greater in the groups in which detomidine was administered. The muzzle-soil distance significantly reduced in all groups five minutes after the sedative administration, remaining smaller for a longer time in the GD0.06. Ataxia in GX1.0 was greater than in GX0.08 and GX1,2, being equivalent to GD0,04 and GD0,06. Analgesia lasted 30 minutes in GD0.06 and 10 minutes in the others. There was reduction of HR in GD0.02 and GD0.04 and atrioventricular block. There was a reduction in TR in GX1,2, GD0.02, GD0,04 and GD0,06. RR decreased in all groups. MAP increased in GD0.02, GD0.04 and GD0.06 five, 20, 30 and 10 minutes after administration of detomidine, respectively. Hyperglycaemia occurred for 120 minutes in all animals receiving detomidine. The frequency of micturition was higher in GD0.06 (2.2 ± 0.8) than in GX0.8 (0.8 ± 0.4). In northern Brazil, detomidine and xylazine promote short duration analgesia and cardiorespiratory alterations, but detomidine causes a greater sedative, hypertensive and hypothermic effect.

https://doi.org/10.29374/2527-2179.bjvm100820
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References

Ambrósio, A. M., Casaes, A. G., Ida, K. K., Souto, M. T. M. R., Zechetto, L. S., Furtado, P. V., Miyashiro, P., Bonomo, C. C. M., Fernandes, G. C., Carvalho, P. H., Silva, L. C. L. C., & Fantoni, D. T. (2012). Differences in blood glucose increase between horses receiving xylazine and detomidine for surgical and non-surgical clinical procedures. Brazilian Journal of Veterinary Research and Animal Science, 49(6), 493-499.

Eger, E. I., Raines, D. E., Shafer, S. L., Hemmings Junior, H. C., & Sonner, J. M. (2008). Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Veterinary Anaesthesia and Analgesia, 107(3), 832-848. http://dx.doi.org/10.1213/ane.0b013e318182aedb. PMid:18713892.

El-Maghraby, H. M., Al-Akraa, A. M., & Ghanem, M. M. (2005). The sedative, analgesic and biochemical effects of romifidine in donkeys. Benha Veterinary Medical Journal, 16, 232-246.

El-Kammar, M. H., & Gad, S. B. (2014). Antagonism of Detomidine-Induced sedation, analgesia, clinicophysiological, and hematobiochemical effects in donkeys using IV Tolazoline or Atipamezole. Journal of Equine Veterinary Science, 34(6), 784-792. http://dx.doi.org/10.1016/j.jevs.2014.02.001.

Figueiró, M. R., Soares, J. H., Ascoli, F. O., Werre, S., & Gómez de Segura, I. Á (2016). Isoflurane MAC determination in dogs using three intensities of constant-current electrical stimulation. Veterinary Anaesthesia and Analgesia, 43(5), 464-471. http://dx.doi.org/10.1111/vaa.12341. PMid:27531057.

Fischer, B. L., Ludders, J. W., Asakawa, M., Fortier, L. A., Fubini, S. L., Nixon, A. J., Radcliffe, R. M., & Erb, H. N. (2009). A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy. Veterinary Anaesthesia and Analgesia, 36(1), 67-76. http://dx.doi.org/10.1111/j.1467-2995.2008.00422.x. PMid:19121161.

Gozalo-Marcilla, M., Gasthuys, F., & Schauvliege, S. (2015). Partial intravenous anesthesia in the horse: a review of intravenous agents used to supplement equine inhalation anesthesia. Part 2: Opioids and alpha-2 adrenoceptor agonists. Veterinary Anaesthesia and Analgesia, 42(1), 1-16. http://dx.doi.org/10.1111/vaa.12196. PMid:24984895.

Gozalo-Marcilla, M., Luna, S. P. L., Crosignani, N., Puoli Filho, J. P. N., Possebon, F. S., Pelligand, L., & Taylor, P. E. (2017). Sedative and antinociceptive effects of detomidine, methadone and different combinations in standing horses. Veterinary Anaesthesia and Analgesia, 44(5), 1116-1127. http://dx.doi.org/10.1016/j.vaa.2017.03.009. PMid:29050998.

Grosenbaugh, D. A., Reinemeyer, C. R., & Figueiredo, M. D. (2011). Pharmacology and therapeutics in donkeys. Equine Veterinary Education, 23(10), 523-530. http://dx.doi.org/10.1111/j.2042-3292.2011.00291.x.

Guirro, E. C. B. P., Sobrinho, G. R., Ferreira, I. M. M., & Valadão, C. A. A. (2009). Injeção epidural de xilazina e amitraz, em equinos: Efeitos antinociceptivos. Ciência Rural, 39(1), 104-109. http://dx.doi.org/10.1590/S0103-84782008005000049.

Hubbell, J. A., Aarnes, T. K., Lerche, P., & Bednarski, R. M. (2012). Evaluation of a midazolam-ketamine-xylazine infusion for total intravenous anesthesia in horses. American Journal of Veterinary Research, 73(4), 470-475. http://dx.doi.org/10.2460/ajvr.73.4.470. PMid:22452492.

Joubert, K. E., Briggs, P., Gerber, D., & Gottschalk, R. G. (1999). The sedative and analgesic effects of detomidinebutorphanol and detomidine alone in donkeys. Journal of the South African Veterinary Association, 70(3), 112-118. http://dx.doi.org/10.4102/jsava.v70i3.769. PMid:10852680.

Kamerling, S. G., Cravens, W. M. T., & Bagwell, C. A. (1988). Objective assessment of detomidine-induced analgesia and sedation in the horse. European Journal of Pharmacology, 151(1), 1-8. http://dx.doi.org/10.1016/0014-2999(88)90685-1. PMid:3416917.

Laster, M. J., Liu, J., Eger, E. I., & Taheri, S. (1993). Electrical stimulation as a substitute for the tail clamp in the determination of minimum alveolar concentration. Veterinary Anaesthesia and Analgesia, 76(6), 1310-1312. http://dx.doi.org/10.1213/00000539-199376060-00021. PMid:8498669.

Le Bars, D., Gozariu, M., & Cadden, S. W. (2001). Animal models of nociception. Pharmacological Reviews, 53(4), 597-652. PMid:11734620.

Lizarraga, I., Sumano, H., & Brumbaugh, G. W. (2004). Pharmacological and pharmacokinetic differences between donkeys and horses. Equine Veterinary Education, 16(2), 102-112. http://dx.doi.org/10.1111/j.2042-3292.2004. tb00275.x.

Lizarraga, I., & Beths, T. (2012). A comparative study of xylazine-induced mechanical hypoalgesia in donkeys and horses. Veterinary Anaesthesia and Analgesia, 39(5), 533-538. http://dx.doi.org/10.1111/j.1467-2995.2012.00725.x. PMid:22574779.

Lizarraga, I., & Janovyak, E. (2013). Comparison of the mechanical hypoalgesic effects of five alpha2-adrenoceptor agonists in donkeys. The Veterinary Record, 173(12), 294. http://dx.doi.org/10.1136/vr.101684. PMid:23878192.

Lizarraga, I., & Castillo-Alcala, F. (2015). Sedative and mechanical hypoalgesic effects of butorphanol in xylazine premedicated donkeys. Equine Veterinary Journal, 47(3), 308-312. http://dx.doi.org/10.1111/evj.12274. PMid:24735190.

Lizarraga, I., Castillo-Alcala, F., Varner, K. M., & Robinson, L. S. (2015). Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage-effect study. The Veterinary Record, 176(8), 202. http://dx.doi.org/10.1136/vr.102569. PMid:25430939.

Love, E. J., Murrell, J. & Whay, H. R. (2011). Thermal and mechanical nociceptive threshold testing in horses: A review. Veterinary Anaesthesia and Analgesia, 38(1), 3-14.

Magdesian, K. G. (2004). Monitoring the critically ill equine patient. Veterinary Clinics Equine Practice, 20(1), 11-39. http://dx.doi.org/10.1016/j.cveq.2003.12.001. PMid:15062457.

Mori, E., Fernandes, W. R., Mirandola, R. M. S., Kubo, G., Ferreira, R. R., Oliveira, J. V., & Gacek, F. (2003). Reference values on serum biochemical parameters of brazilian donkey (Equus asinus) breed. Journal of Equine Veterinary Science, 23(8), 358-364. http://dx.doi.org/10.1016/S0737-0806(03)01025-6.

Mostafa, M. B., Farag, K. A., Zomor, E., & Bashandy, M. M. (1995). The sedative and analgesic effects of detomidine (Domosedan) in donkeys. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, 42(5), 351-356. http://dx.doi.org/10.1111/j.1439-0442.1995.tb00387.x. PMid:8578910.

Murrell, J. C., & Hellebrekers, L. J. (2005). Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. Veterinary Anaesthesia and Analgesia, 32(3), 117-127. http://dx.doi.org/10.1111/j.1467-2995.2005.00233.x. PMid:15877658.

Parry, B. W. (1986). Practical assessment of the circulatory status of equine colic cases. The Compendium on Continuing Education for the Practicing Veterinarian, 8(5) 236-246.

Ramsay, E. C., Geiser, D. R., Carter, W., & Tobin, T. (2002). Serum concentrations and effects of detomidine delivered orally to horses in three different mediums. Veterinary Anaesthesia and Analgesia, 29(4), 219-222. http://dx.doi.org/10.1046/j.1467-2995.2002.00096.x. PMid:28404366.

Ringer, S. K., Schwarzwald, C. C., Portier, K. G., Ritter, A., & Bettschart-Wolfensberger, R. (2012a). Effects on cardiopulmonary function and oxygen delivery of doses of romifidine and xylazine followed by constant rate infusions in standing horses. Veterinary Journal, 195(2), 228-234. http://dx.doi.org/10.1016/j.tvjl.2012.06.036. PMid:22841452.

Ringer, S. K., Portier, K. G., Fourel, I., & Bettschart-Wolfensberger, R. (2012b). Development of a xylazine constant rate infusion with or without butorphanol for standing sedation of horses. Veterinary Anaesthesia and Analgesia, 39(1), 1-11. http://dx.doi.org/10.1111/j.1467-2995.2011.00653.x. PMid:22103355.

Ringer, S. K., Portier, K., Torgerson, P. R., Castagno, R., & Bettschart-Wolfensberger, R. (2013). The effects of a loading dose followed by constant rate infusion of xylazine compared with romifidine on sedation, ataxia and response to stimuli in horses. Veterinary Anaesthesia and Analgesia, 40(2), 157-165. http://dx.doi.org/10.1111/j.1467-2995.2012.00784.x. PMid:23051857.

Simenew, K., Gezahegne, M., Getachew, M., Wondyefraw, M., Alemayehu, L. & Eyob, I. (2011). References values of clinically important physiological, hematological and serum biochemical parameters of apparently healthy working equids of Ethiopia. Global Veterinaria, 7(1), 1-6.

Zeiler, G. E. (2015). A review of clinical approaches to antagonism of alpha2‐adrenoreceptor agonists in the

horse. Equine Veterinary Education, 27(1), 48-54. http://dx.doi.org/10.1111/eve.12249.

Yamashita, K., Tsubakishita, S., Futaok, S., Ueda, I., Hamaguchi, H., Seno, T., Katoh, S., Izumisawa, Y., Kotani, T., & Muir, W. W. (2000). Cardiovascular effects of medetomidine, detomidine and xylazine in horses. The Journal of Veterinary Medical Science, 62(10), 1025-1032. http://dx.doi.org/10.1292/jvms.62.1025. PMid:11073071.

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Copyright (c) 2020 Fernanda Vieira Henrique, Roberta Nunes Parentoni, Arthur Willian de Lima Brasil, Rafaela Alves Dias, Ana Lucélia de Araújo Araújo, Rodrigo de Souza Mendes, Emanuel Ferreira Martins Filho, João Moreira da Costa Neto, Almir Pereira de Souza, Pedro Isidro da Nóbrega Neto