EVALUATION OF ORAL ADMINISTRATION OF URSODEOXYCHOLIC ACID (AUDC) IN THE DIAGNOSIS OF NATURAL INFECTION IN CATS Platynosomum illiciens
ABSTRACT. Leal P.D.S., Campos D.P., Rodrigues M. de L. de A., Botelho G.G. & Labarthe N.V. [Evaluation of oral administration of ursodeoxycholic acidin the diagnosis of natural infection in cats by Platynosomum illiciens]. Avaliação da administração oral de ácido ursodesoxicólico (AUDC) no diagnóstico da infecção natural por Platynosomum illiciens em gatos. Revista Brasileira de Medicina Veterinária, 33(4):229-233, 2011. Curso de Pós-Graduação de Ciências Veterinárias. Universidade Federal Rural do Rio de Janeiro, BR 465 km 7, Seropédica, RJ 23890-000, Brazil. Email: email@example.com Although infection by feline Platinosomum illiciens is common in Southeastern Brazil, in vivo diagnosis is rare. This disease presents with inflammation and obstruction of the bile ducts and, over time, the host can lead to death. The difficulty in diagnosis by parasitological laboratory results from the fact that eggs are heavy, requiring methods of sedimentation to be found, and its elimination in the feces be intermittent and few in number. So, we decided to evaluate whether a drug with choleretic action and bile duct, characteristic of ursodeoxycholic acid, would increase the concentration of parasite eggs in the feces of infected cats. Therefore, in the first half of 2003, 16 cats from a colony located in the western area of the city of Rio de Janeiro, Brazil, were included, without restriction as to age, gender or medical conditions, although all animals were sick and for the euthanasia by veterinarians responsible. The animals were housed individually for 10 days and, where defecated, a stool sample was collected. All samples were examined by techniques of sedimentation and flotation. On the fifth day after the beginning of the collection of all stool samples received ursodeoxycholic acid (10-15mg/kg) in a single dose. On the 10th day after the collection of stool samples, all animals were euthanized in accordance with the determination of the Federal Council of Veterinary Medicine, followed by autopsy for detection of eggs and specimens of P. illiciens in the gallbladder and bile ducts. Among the 16 animals, 12 were parasitized by P. illiciens (75%), of which nine adult forms harbored in the liver (56.25%). 10 animals (63%) had eggs in fecal samples and in the gallbladder. The administration of ursodeoxycholic acid did not affect the sensitivity of diagnostic techniques, although the number of eggs in the feces of animals has increased. Stool examination by sedimentation of serial samples, was more sensitive than by flotation.