Histopathologic characterization of urinary bladders associated with Bovine Enzootic Hematuria

  • Maria Aparecida da Silva
  • Dyeime Ribeiro de Sousa
  • Ana Paula Madureira
  • Louisiane de Carvalho Nunes
Keywords: HEB, bladder, neoplasm, histogenesis

Abstract

ABSTRACT. da Silva M.A., de Sousa D.R., Madureira A.P. & Nunes L. de C. [Histopathologic characterization of urinary bladders associated with Bovine Enzootic Hematuria]. Caracterização histopatológica de bexigas associadas à Hematúria Enzoótica Bovina. Revista Brasileira de Medicina Veterinária, 34(4):319-326, 2012. Departamento de Medicina Veterinária, Centro de Ciências Agrárias, Universidade Federal do Espírito Santo, Alto Universitário, s/no Cx. Postal 16, Guararema, Alegre, 29500- 000, ES, Brasil. E-mail: louisiane.nunes@ufes.br Bovine enzootic hematúria is caused by poisoning Pteridium aquilinum and characterized by the presence of blood in the urine and bladder neoplasms development. The objective of this study was to characterize histopathologically bladders of bovines associated with enzootic hematuria and obtain epidemiological data related to this disease from Caparaó microrregion in the state of Espírito Santo, Brazil. Urinary bladders from cattle coming from municipalities with the presence of P. aquilinum presenting macroscopic lesions and/or hematuria were selected at the slaughterhouse from the Muniz Freire, ES. Samples with four fragments of each bladder were fixed in formalin 10%. Submitted to routine histological processing and ranked them morphologically. The epidemiological data revealed that the bladders used were from bovines of the municipalities: Guaçuí, Muniz Freire, Alegre, Iúna, Afonso Cláudio, ES, and Mutum, MG. Of bovines, 36.95% were males and 63.05% females. Macrohematuria was observed in 50% and microhematuriain 50% of the bladders. The macroscopic lesions included petechia, papillomatous lesions, hemangiomatous lesions, lesions in high relief plate-shaped, and low relief. Non-neoplastic lesions were observed in 100% of the samples. The non-neoplastic processes revealed dysplasia, clear cell metaplasia, hyperplasia, hemorrhage, cystic cystitis, Brunn nests, inflammation, vascular proliferation, vascular dilatation, vascular thickening, and vascular ectasia. Neoplastic lesions were found in 56.52% of the bladders, and of these 53.85% were epithelial origin and 88.46% mesenchymal origin. The neoplastic processes were urothelial carcinoma, carcinoma in situ, adenocarcinoma, hemangioma, myxoma and hemangiosarcoma. The presence of neoplasms was significant (p<0.05) in the caudal portion of the bladder. There was a higher frequency (p<0.05) of dysplasia, clear cell metaplasia, inflammation and vascular thickening in bladders with neoplasm. It isconcluded that in bladders of cattle with enzootic haematuria have non-neoplastic and neoplastic lesions, isolated or associated, which are involved in clinical signs of disease. The epidemiological data showed that there are animals with BEH in the municipalities of the Caparaó microrregion of the State of Espírito Santo, Brazil and neighboring regions.

Published
2012-12-22
How to Cite
da Silva, M. A., de Sousa, D. R., Madureira, A. P., & Nunes, L. de C. (2012). Histopathologic characterization of urinary bladders associated with Bovine Enzootic Hematuria. Brazilian Journal of Veterinary Medicine, 34(4), 319-326. Retrieved from http://rbmv.org/index.php/BJVM/article/view/732

Most read articles by the same author(s)