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ABSTRACT. Leal P.D.S., Paes de Almeida E.C. & Lopes C.W.G. [Skin disease diagnosis Pyogranulomatous Nocardia spp. in a Labrador Retriever bitch with hypothyroidism, Rio de Janeiro, Brazil - Case report.] Diagnóstico de dermatopatia piogranulomatosa por Nocardia spp. numa cadela Labrador Retriever com hipotireoidismo, Rio de Janeiro, Brasil - Relato de caso. Revista Brasileira de Medicina Veterinária, 38(2):203-209, 2016. Programa de Pós-Graduação de Ciências Veterinárias, Anexo 1, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Campus Seropédica, BR 465 Km 7, Seropédica, RJ 23890-000, Brasil. E-mail: email@example.com A case of nocardiosis was reported in cutaneous and subcutaneous abscesses in a Labrador Retriever bitch with hypothyroidism, 11 years old, castrated, weighing 22 kg, served in the Intensive Care Unit and Emergency Veterinary, lesions appeared 30 days after wounds by biting dogs in the chest and abdomen, with fistula formation in the healing of lacerations in the region caused by bites. Biopsy and bacterial culture with sensitivity were requested. The bacterial culture revealed the presence of microorganism associated with the histopathological findings of lesions characterized by pyogranulomatous reaction when stained by PAS identified extruturas like round colonies of the genus Nocardia. The antibiogram of the isolated microorganisms indicated that was sensitive to antibiotics, enrofloxacin, gentamicin, ciprofloxacin and imipenem. Treatment was established with enrofloxacin 5 mg/kg body weight every 12 hours for a period of 22 days, with improvement; but there is no cure, so opted for the surgical debridement and removal of fistulae and increased the dose of enrofloxacin to 10 mg/kg, with improvement dependent antibiotic therapy, when it opted for pulse therapy control of pyogranulomas.