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ABSTRACT. Costa T.S., Lopes N.L., Carvalho J.R.G., Mascarenhas M.B., Veiga C.C.P., Ramadinha R.R. & Fernandes J.I. [Multilobular tumor of bone in a dog - Case report.] Tumor ósseo multilobular em cão - Relato de caso. Revista Brasileira de Medicina Veterinária, 38(Supl.2):159-163, 2016. Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal Rural do Rio de Janeiro, BR 465 Km 7, Seropédica, RJ 23897-000, Brasil. E-mail: firstname.lastname@example.org The multilobular tumor of bone is a rare neoplasm, originating primarily in the osseous tissue, which typically affects the skull bones, in middle-aged animals. Clinical signs depends on the tumor location, aggressiveness, and being related to compression of adjacent structures. Imaging exams such as radiography and computed tomography may be helpful in supporting the diagnosis. Histopathological findings have characteristic morphology and allow its differentiation from other primary bone sarcomas, which have more aggressive biological behavior and poor prognosis. The treatment by aggressive surgical resection can result in long-term disease remission and survival time. This paper aimed to report a case of multilobular tumor of bone, diagnosed in a female Dalmatian breed, spayed, 12 years of age, reporting the clinical and laboratory findings and the conduct adopted to reach the diagnose. The justification for this paper consists in scarce brazilian literature on this subject.