Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges

Keywords: Stem cells, Mesenchymal stem/stromal cells, Cell therapy

Abstract

The potential of stem cell-based therapy was accompanied by high expectations and led, consequently, to an increase in clinical translational investments. Mesenchymal stem/stromal cells (MSCs) became the cell-based product most experimentally studied worldwide. However, uncertainties about the mechanisms and the in vivo identity of MSCs impose concerns about their large-scale use in regenerative medicine. This review comprises a historical summary on MSC, a critical discussion about their identity and function, and the ongoing challenges for their use in therapy and tissue bioengineering.

Published
2020-06-11
How to Cite
Rossi, M. I. D., & Bonfim, D. C. (2020). Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges. Brazilian Journal of Veterinary Medicine, 42(1), e112020. https://doi.org/10.29374/2527-2179.bjvm112020
Section
Review