Detomidine and xylazine, at different doses, in donkeys (Equus asinus)

  • Roberta Nunes Parentoni Universidade Federal da Paraíba, João Pessoa, PB, Brazil. https://orcid.org/0000-0002-4067-1947
  • Fernanda Vieira Henrique Programa de residência multiprofissional, Universidade Federal de Campina Grande (UFCG), Campus de Patos, PB, Brazil https://orcid.org/0000-0002-8956-8983
  • Arthur Willian de Lima Brasil Universidade Federal de Rondônia, Campus Rolim de Moura, RO, Brazil.
  • Rafaela Alves Dias Autonomus. Campina Grande, PB, Brazil
  • Ana Lucélia de Araújo Araújo Instituto Federal de Educação Ciência e Tecnologia da Paraíba. Souza, PB, Brazil.
  • Rodrigo de Souza Mendes Universidade Potiguar (UNP), Natal, RN, Brazil.
  • Emanuel Ferreira Martins Filho FAPESB (Fundação de Amparo à Pesquisa do Estado da Bahia - (FAPESB), Salvador, BA, Brazil. https://orcid.org/0000-0002-0542-5468
  • João Moreira da Costa Neto Universidade Federal da Bahia, Salvador, BA, Brazil.
  • Almir Pereira de Souza Universidade Federal de campina Grande. Patos, PB, Brazil.
  • Pedro Isidro da Nóbrega Neto Universidade Federal de Campina Grande. Patos, PB, Brazil https://orcid.org/0000-0002-7307-3214
Keywords: alpha-2 adrenergic agonist, analgesia, equine, sedation

Abstract

The effects of detomidine and xylazine in northeasters donkeys were compared. Six animals participated, randomly, of all experimental groups: xylazine 10%, 0.8 mg/kg (xylazine group 0.8 - GX0.8), 1.0 mg/kg (GX1.0) and 1, 2 mg/kg (GX1.2); and detomidine 1%, 0.02 mg/kg (Detomidine group 0.02 - GD0.02), 0.04 mg/kg (GD0.04) and 0.06 mg/kg (GD0.06) intravenous. Heart rate (HR) and respiratory rate (RR), rectal temperature (RT), mean arterial pressure (MAP), blood glucose, sedation, analgesia, ataxia, arrhythmias and urination were monitored. Duration of sedation was greater in the groups in which detomidine was administered. The muzzle-soil distance significantly reduced in all groups five minutes after the sedative administration, remaining smaller for a longer time in the GD0.06. Ataxia in GX1.0 was greater than in GX0.08 and GX1,2, being equivalent to GD0,04 and GD0,06. Analgesia lasted 30 minutes in GD0.06 and 10 minutes in the others. There was reduction of HR in GD0.02 and GD0.04 and atrioventricular block. There was a reduction in TR in GX1,2, GD0.02, GD0,04 and GD0,06. RR decreased in all groups. MAP increased in GD0.02, GD0.04 and GD0.06 five, 20, 30 and 10 minutes after administration of detomidine, respectively. Hyperglycaemia occurred for 120 minutes in all animals receiving detomidine. The frequency of micturition was higher in GD0.06 (2.2 ± 0.8) than in GX0.8 (0.8 ± 0.4). In northern Brazil, detomidine and xylazine promote short duration analgesia and cardiorespiratory alterations, but detomidine causes a greater sedative, hypertensive and hypothermic effect.

Published
2020-01-23
How to Cite
Parentoni, R. N., Henrique, F. V., Brasil, A. W. de L., Dias, R. A., Araújo, A. L. de A., Mendes, R. de S., Martins Filho, E. F., Costa Neto, J. M. da, de Souza, A. P., & da Nóbrega Neto, P. I. (2020). Detomidine and xylazine, at different doses, in donkeys (Equus asinus). Brazilian Journal of Veterinary Medicine, 42(1), e100820. https://doi.org/10.29374/2527-2179.bjvm100820
Section
Scientific articles